The Natarajan laboratory We are interested in the fundamental process of cell fate specification during mammalian development and differentiation at single-cell level. The group aims to understand general paradigms of cell state and fate specification, with a particular interest in transcriptional and epigenetic regulatory networks, and their crosstalk with cell cycle, metabolism and fundamental cellular processes.
We have a interdisciplinary foundation and combine wet-lab experiments with theoretical models and computational approaches at single-cell and bulk level to uncover principles governing cell fate decisions, and their consequences in development and disease. We leverage different developmental (ESCs/hiPSCs), differentiation (CNS, immune) models alongside molecular, cellular and computational approaches.
We study how transcriptional regulation is governed globally during cell cycle and across phases in ESCs/iPSCs at single-cell level.
We utilise cell cycle sensors combined with candidate gene perturbation and single-cell profiling to understand different mechanisms involved in cell cycle regulation of pluripotency and differentiation.
Distinct cell cycle changes accompany stem cell differentiation and can drive cell-fate responses.
We combine state-of-art single-cell genomics and computational tools to investigate transcriptional and epigenetic changes that accompany cell-fate specification.
We have a strong interest in development, extension and utilisation of new experimental and computational methods for single-cell biology.
Working closely with collaborators, we develop new computational tools that integrate measurements from several single-cell technologies.
Masters : Tomasso Asquini, Konrad Uscilo, Da Eun Lee, Valentina Hekimova, Maja Brask, Sophia Hald
Bachelors : Maja Brask, Felix Pedersen
PhD : HyunTae Choi, Simon Jakobsen, Andreas Moller
Postdoc: Deyong Zhu
Our research is possible due to generous support form: