The Natarajan laboratory investigates the fundamental process of cell cycle during embryonic development at single-cell level. We focus on understanding how the crosstalk between cell cycle and gene expression influences cell-state and fate decisions in embryonic stem cells.
We apply and develop a wide variety of experimental and computational tools to study mechanisms involved in stem cells state and during their differentiation. These bulk and single-cell approaches include advanced molecular biology, state-of-art imaging, Flow cytometry, genome editing and variety of single-cell functional genomics methods. Our research aims to gain a deeper ‘system biology’ single-cell view of biological systems.
We study how transcriptional regulation is governed globally during cell cycle and across phases in embryonic stem cells at single-cell level.
We utilise FUCCI cell cycle sensors combined with candidate gene perturbation and single-cell profiling to understand different mechanisms involved in cell cycle regulation of pluripotency.
Distinct cell cycle changes accompany stem cell differentiation and can drive cell-fate responses.
We combine state-of-art single-cell methods to investigate how underlying single-cell gene expression dynamics contribute to cell-fate decisions.
We have a strong interest in development, extension and utilisation of new experimental and computational methods for single-cell biology.
Working closely with collaborators, we develop new computational tools that integrate measurements from several single-cell technologies.
The Natarajan laboratory officially starts at Functional Genomics Unit at SDU. We look forward to setting up setting up single-cell experimental and computational capabilities for stem cells and single-cell genomics.
September: Valentina Hekimova and Andreas Møller are starting their Masters thesis projects. Maja Brask starts her individual study assignment (ISA) and Simon Jakobsen is starting his PhD.
Welcome Valentina, Andreas, Maja and Simon
The Natarajan lab was awarded the NNF Bioscience and Basic Biomedicine project grant and Villum Young Investigator award. Congratulations!!!
Valentina Hekimova and Andreas Møller both succesfully defended their Masters thesis.
Valentina will be changing fields and pursuing her interests in software design and consulting. We wish you best!!
Andreas will re-join the lab as PhD student. Welcome back!
The Natarajan lab was awarded the NNF Synergy grant along with Brewer (SDU), Sedzinski (KU) and Kutter (KU) labs. Congratulations to all!!!
Andreas Møller received Sino Danish Centre funding to begin his PhD in the lab and also published his first author paper
Double Congratulations !!
Our research is possible due to generous support form:
Functional Genomics and Metabolism Unit,
Department of Biochemistry and Molecular Biology
University of Southern Denmark
Campusvej 55, 5230 Odense, Denmark
+45 6550 8929