The Natarajan laboratory investigates the fundamental process of cell cycle during embryonic development at single-cell level. We focus on understanding how the crosstalk between cell cycle and gene expression influences cell-state and fate decisions in embryonic stem cells.
We apply and develop a wide variety of experimental and computational tools to study mechanisms involved in stem cells state and during their differentiation. These bulk and single-cell approaches include advanced molecular biology, state-of-art imaging, Flow cytometry, genome editing and variety of single-cell functional genomics methods. Our research aims to gain a deeper ‘system biology’ single-cell view of biological systems.
We study how transcriptional regulation is governed globally during cell cycle and across phases in embryonic stem cells at single-cell level.
We utilise FUCCI cell cycle sensors combined with candidate gene perturbation and single-cell profiling to understand different mechanisms involved in cell cycle regulation of pluripotency.
Distinct cell cycle changes accompany stem cell differentiation and can drive cell-fate responses.
We combine state-of-art single-cell methods to investigate how underlying single-cell gene expression dynamics contribute to cell-fate decisions.
We have a strong interest in development, extension and utilisation of new experimental and computational methods for single-cell biology.
Working closely with collaborators, we develop new computational tools that integrate measurements from several single-cell technologies.
We are always interested in passionate, talented and inquisitive students (Bachelors, ISA, Masters and PhD),
Post-doctoral fellows and visitors interested in single-cell, systems and developmental biology, computational modelling and
big data analysis to join our team.
If you are interested in our lab, please email a tailored cover letter, highlighting your specific interest and motivation to Kedar Natarajan ( firstname.lastname@example.org).
We have two open positions Postdoc positions in the lab to study
cell cycle and transcriptional regulation using single-cell genomics.
Computational position: click here.
Experimental/Systems position: click here.
The Natarajan laboratory officially starts at Functional Genomics and Metabolism Unit. In the coming months, we will set up experimental capabilities for stem cell work, single-cell genomics and computational analysis of single-cell data.
Valentina Hekimova is starting in the lab from September 2018 for a year to pursue her Master’s thesis. She is currently studying Masters in Computational Biomedicine at SDU and has a background in software development. Valentina will be working on computational analysis of single-cell omics datasets
Maja Brask joins the lab from September 2018 for an ISA project. Maja currently studies Biochemistry and Molecular Biology at SDU and is interested in functional genomics, CRISPR and stem cell biology.
Simon Jakobsen is starting as a PhD student in the lab. Simon is an molecular biologist with interest in innovative usages of Next Generation Sequencing and data-science.
Andreas Møller joins the lab from September 2018 for a joint Master's project with Grøntved Lab. Andreas is currently pursuing his studies at Sino Danish Center, and he is interested in computational analysis of single-cell RNA-seq data.
Felix Boel Pedersen will be starting in the lab from February 2019 for his Master’s project and thesis. Felix is currently studying Masters in Computational Biomedicine at SDU and has a strong interest in gene editing methods. He will be working on CRISPR-based gene targeting methods and single-cell transcriptomics.
The Natarajan lab was awarded the Novo Nordisk Foundation Project grant in Bioscience and Basic Biomedicine 2018. Congratulations!!!
Our research is possible due to generous support form:
We are based in the Functional Genomics and Metabolism Unit , within Department of Biochemistry and Molecular Biology at the University of Southern Denmark, which is a great place to start and progress a scientific career in science. We are an interdisciplinary team where we learn and integrate both experimental and computational approaches to address fundamental biological questions.
Functional Genomics and Metabolism Unit,
Department of Biochemistry and Molecular Biology
University of Southern Denmark
Campusvej 55, 5230 Odense, Denmark
+45 6550 8929